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Active DNA demethylation at enhancers during the vertebrate phylotypic period

The vertebrate body plan and organs are shaped during a conserved embryonic phase called the phylotypic stage. However, the mechanisms that guide the epigenome through this transition and their evolutionary conservation remain elusive. Here we report widespread DNA demethylation of enhancers during...

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הוצא לאור ב:	Nat Genet
Main Authors:	Bogdanović, Ozren, Smits, Arne H, de la Calle Mustienes, Elisa, Tena, Juan J, Ford, Ethan, Williams, Ruth, Senanayake, Upeka, Schultz, Matthew D, Hontelez, Saartje, van Kruijsbergen, Ila, Rayon, Teresa, Gnerlich, Felix, Carell, Thomas, Veenstra, Gert Jan C, Manzanares, Miguel, Sauka-Spengler, Tatjana, Ecker, Joseph R, Vermeulen, Michiel, Gómez-Skarmeta, José Luis, Lister, Ryan
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2016
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5912259/ https://ncbi.nlm.nih.gov/pubmed/26928226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3522
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Active DNA demethylation at enhancers during the vertebrate phylotypic period

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