Active DNA demethylation at enhancers during the vertebrate phylotypic period

The vertebrate body plan and organs are shaped during a conserved embryonic phase called the phylotypic stage. However, the mechanisms that guide the epigenome through this transition and their evolutionary conservation remain elusive. Here we report widespread DNA demethylation of enhancers during...

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Publié dans:Nat Genet
Auteurs principaux: Bogdanović, Ozren, Smits, Arne H, de la Calle Mustienes, Elisa, Tena, Juan J, Ford, Ethan, Williams, Ruth, Senanayake, Upeka, Schultz, Matthew D, Hontelez, Saartje, van Kruijsbergen, Ila, Rayon, Teresa, Gnerlich, Felix, Carell, Thomas, Veenstra, Gert Jan C, Manzanares, Miguel, Sauka-Spengler, Tatjana, Ecker, Joseph R, Vermeulen, Michiel, Gómez-Skarmeta, José Luis, Lister, Ryan
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912259/
https://ncbi.nlm.nih.gov/pubmed/26928226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3522
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