Active DNA demethylation at enhancers during the vertebrate phylotypic period

The vertebrate body plan and organs are shaped during a conserved embryonic phase called the phylotypic stage. However, the mechanisms that guide the epigenome through this transition and their evolutionary conservation remain elusive. Here we report widespread DNA demethylation of enhancers during...

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Publicado no:Nat Genet
Main Authors: Bogdanović, Ozren, Smits, Arne H, de la Calle Mustienes, Elisa, Tena, Juan J, Ford, Ethan, Williams, Ruth, Senanayake, Upeka, Schultz, Matthew D, Hontelez, Saartje, van Kruijsbergen, Ila, Rayon, Teresa, Gnerlich, Felix, Carell, Thomas, Veenstra, Gert Jan C, Manzanares, Miguel, Sauka-Spengler, Tatjana, Ecker, Joseph R, Vermeulen, Michiel, Gómez-Skarmeta, José Luis, Lister, Ryan
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912259/
https://ncbi.nlm.nih.gov/pubmed/26928226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3522
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