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A Review of Salvinorin Analogs and their Kappa-Opioid Receptor Activity
The plant metabolite salvinorin A potently and selectively agonizes the human kappa-opioid receptor, an emerging target for next-generation analgesics. Here we review analogs of the salvinorin chemotype and their effects on selectivity, affinity and potency. Extensive peripheral modifications using...
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| 發表在: | Bioorg Med Chem Lett |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5912166/ https://ncbi.nlm.nih.gov/pubmed/29615341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.03.029 |
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