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Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding
Developmentally regulated accessory subunits dictate PRC2 function. Here, we report the crystal structures of a 120KDa heterotetrameric complex consisting of Suz12, Rbbp4, Jarid2 and Aebp2 fragments that is minimally active in nucleosome binding, and of an inactive binary complex of Suz12 and Rbbp4....
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| Gepubliceerd in: | Mol Cell |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5912153/ https://ncbi.nlm.nih.gov/pubmed/29499137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.039 |
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