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Taking aim at glycolysis with CDK8 inhibitors
Dependence on glycolysis in aerobic conditions, a frequent metabolic derangement in cancer cells, suggests a therapeutic opportunity. Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional co-activator complex, has emerged as an upstream inducer of glycolysis and...
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| Publicado no: | Trends Endocrinol Metab |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5911231/ https://ncbi.nlm.nih.gov/pubmed/29475579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tem.2018.02.005 |
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