Increased autophagy blocks HER2-mediated breast tumorigenesis

Allelic loss of the autophagy gene, beclin 1/BECN1, increases the risk of patients developing aggressive, including human epidermal growth factor receptor 2 (HER2)-positive, breast cancers; however, it is not known whether autophagy induction may be beneficial in preventing HER2-positive breast tumo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Vega-Rubín-de-Celis, Silvia, Zou, Zhongju, Fernández, Álvaro F., Ci, Bo, Kim, Min, Xiao, Guanghua, Xie, Yang, Levine, Beth
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2018
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910832/
https://ncbi.nlm.nih.gov/pubmed/29610308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717800115
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