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Autophagy Protects against Sindbis Virus Infection of the Central Nervous System

Autophagy functions in antiviral immunity. However, it is not yet known whether endogenous autophagy genes protect against viral disease in vertebrates. Using three different approaches to inactivate the autophagy gene Atg5 in virally-infected neurons, we found that loss of Atg5 function increases m...

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Detalhes bibliográficos
Main Authors: Orvedahl, Anthony, MacPherson, Sarah, Sumpter, Rhea, Tallóczy, Zsolt, Zou, Zhongju, Levine, Beth
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860265/
https://ncbi.nlm.nih.gov/pubmed/20159618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.01.007
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