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Autophagy Protects against Sindbis Virus Infection of the Central Nervous System

Autophagy functions in antiviral immunity. However, it is not yet known whether endogenous autophagy genes protect against viral disease in vertebrates. Using three different approaches to inactivate the autophagy gene Atg5 in virally-infected neurons, we found that loss of Atg5 function increases m...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Orvedahl, Anthony, MacPherson, Sarah, Sumpter, Rhea, Tallóczy, Zsolt, Zou, Zhongju, Levine, Beth
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860265/
https://ncbi.nlm.nih.gov/pubmed/20159618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.01.007
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