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The Effect of Size and Shape of RNA Nanoparticles on Biodistribution
Drugs with ideal pharmacokinetic profile require long half-life but little organ accumulation. Generally, PK and organ accumulation are contradictory factors: smaller size leads to faster excretion and shorter half-lives and thus a lower tendency to reach targets; larger size leads to longer circula...
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| Publicado no: | Mol Ther |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Gene & Cell Therapy
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5910665/ https://ncbi.nlm.nih.gov/pubmed/29402549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.12.018 |
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