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Size, Shape, and Sequence-Dependent Immunogenicity of RNA Nanoparticles

RNA molecules have emerged as promising therapeutics. Like all other drugs, the safety profile and immune response are important criteria for drug evaluation. However, the literature on RNA immunogenicity has been controversial. Here, we used the approach of RNA nanotechnology to demonstrate that th...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Guo, Sijin, Li, Hui, Ma, Mengshi, Fu, Jian, Dong, Yizhou, Guo, Peixuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701797/
https://ncbi.nlm.nih.gov/pubmed/29246318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.10.010
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