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Switch of mitochondrial superoxide dismutase into a prooxidant peroxidase in manganese-deficient cells and mice

Superoxide radical anion (O(2)(•−)) and other Reactive Oxygen Species (ROS) are constantly produced during respiration. In mitochondria, the dismutation of O(2)(•−) is accelerated by the mitochondrial superoxide dismutase 2 (SOD2), an enzyme that has been traditionally associated with antioxidant pr...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Ganini, Douglas, Santos, Janine H., Bonini, Marcelo G., Mason, Ronald P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910218/
https://ncbi.nlm.nih.gov/pubmed/29398562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.01.007
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