Mutant cartilage oligomeric matrix protein (COMP) compromises bone integrity, joint function and the balance between adipogenesis and osteogenesis

Mutations in COMP (cartilage oligomeric matrix protein) cause severe long bone shortening in mice and humans. Previously, we showed that massive accumulation of misfolded COMP in the ER of growth plate chondrocytes in our MT-COMP mouse model of pseudoachondroplasia (PSACH) causes premature chondrocy...

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Detalhes bibliográficos
Publicado no:Matrix Biol
Main Authors: Coustry, Francoise, Posey, Karen L., Maerz, Tristan, Baker, Kevin, Abraham, Annie M., Ambrose, Catherine G., Nobakhti, Sabah, Shefelbine, Sandra J., Bi, Xiaohong, Newton, Michael, Gawronski, Karissa, Remer, Lindsay, Veerisetty, Alka C., Hossain, Mohammad G., Chiu, Frankie, Hecht, Jacqueline T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910205/
https://ncbi.nlm.nih.gov/pubmed/29309831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2017.12.014
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