RNAi Reduces Expression and Intracellular Retention of Mutant Cartilage Oligomeric Matrix Protein

Mutations in cartilage oligomeric matrix protein (COMP), a large extracellular glycoprotein expressed in musculoskeletal tissues, cause two skeletal dysplasias, pseudoachondroplasia and multiple epiphyseal dysplasia. These mutations lead to massive intracellular retention of COMP, chondrocyte death...

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Detalhes bibliográficos
Main Authors: Posey, Karen L., Liu, Peiman, Wang, Huiqiu R., Veerisetty, Alka C., Alcorn, Joseph L., Hecht, Jacqueline T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858657/
https://ncbi.nlm.nih.gov/pubmed/20421976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010302
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