CDKN2A/B T2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets

Genome-wide association studies link the CDKN2A/B locus with type 2 diabetes (T2D) risk, but mechanisms increasing risk remain unknown. The CDKN2A/B locus encodes cell cycle inhibitors p14, p15, and p16; MTAP; and ANRIL, a long noncoding RNA. The goal of this study was to determine whether CDKN2A/B...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Kong, Yahui, Sharma, Rohit B., Ly, Socheata, Stamateris, Rachel E., Jesdale, William M., Alonso, Laura C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910004/
https://ncbi.nlm.nih.gov/pubmed/29432124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1055
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