Lenalidomide induces interleukin-21 production by T cells and enhances IL21-mediated cytotoxicity in chronic lymphocytic leukemia B cells

The immunomodulatory drug lenalidomide has demonstrated efficacy in chronic lymphocytic leukemia (CLL) patients, despite a lack of direct cytotoxic effect in vitro. The mechanism of lenalidomide efficacy in vivo is thought to occur via a combination of enhanced immune activity and an alteration of t...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Browning, Rebekah L., Byrd, William H., Gupta, Nikhil, Jones, Jeffrey, Mo, Xiaokui, Hertlein, Erin, Yu, Lianbo, Muthusamy, Natarajan, Byrd, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909974/
https://ncbi.nlm.nih.gov/pubmed/27287425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0291
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