Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

Nuclear shape and architecture influence gene localization, mechanotransduction, transcription, and cell function. Abnormal nuclear morphology and protrusions termed “blebs” are diagnostic markers for many human afflictions including heart disease, aging, progeria, and cancer. Nuclear blebs are asso...

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Bibliografiske detaljer
Udgivet i:Mol Biol Cell
Main Authors: Stephens, Andrew D., Liu, Patrick Z., Banigan, Edward J., Almassalha, Luay M., Backman, Vadim, Adam, Stephen A., Goldman, Robert D., Marko, John F.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2018
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909933/
https://ncbi.nlm.nih.gov/pubmed/29142071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-06-0410
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