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CUX1 stimulates APE1 enzymatic activity and increases the resistance of glioblastoma cells to the mono-alkylating agent temozolomide

BACKGROUND: Cut Like homeobox 1 (CUX1), which encodes an auxiliary factor in base excision repair, resides on 7q22.1, the most frequently and highly amplified chromosomal region in glioblastomas. The resistance of glioblastoma cells to the mono-alkylating agent temozolomide is determined to some ext...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Kaur, Simran, Ramdzan, Zubaidah M, Guiot, Marie-Christine, Li, Li, Leduy, Lam, Ramotar, Dindial, Sabri, Siham, Abdulkarim, Bassam, Nepveu, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909652/
https://ncbi.nlm.nih.gov/pubmed/29036362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox178
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