Diff-seq: A high throughput sequencing-based mismatch detection assay for DNA variant enrichment and discovery

Much of the within species genetic variation is in the form of single nucleotide polymorphisms (SNPs), typically detected by whole genome sequencing (WGS) or microarray-based technologies. However, WGS produces mostly uninformative reads that perfectly match the reference, while microarrays require...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Aggeli, Dimitra, Karas, Vlad O, Sinnott-Armstrong, Nicholas A, Varghese, Vici, Shafer, Robert W, Greenleaf, William J, Sherlock, Gavin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Methods Online
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909455/
https://ncbi.nlm.nih.gov/pubmed/29361139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky022
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