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Avasimibe Encapsulated in Human Serum Albumin Blocks Cholesterol Esterification for Selective Cancer Treatment

Undesirable side effects remain a significant challenge in cancer chemotherapy. Here we report a strategy for cancer-selective chemotherapy by blocking acyl-CoA cholesterol acyltransferase-1 (ACAT-1)-mediated cholesterol esterification. To efficiently block cholesterol esterification in cancer in vi...

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發表在:ACS Nano
Main Authors: Lee, Steve Seung-Young, Li, Junjie, Tai, Jien Nee, Ratliff, Timothy L., Park, Kinam, Cheng, Ji-Xin
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909415/
https://ncbi.nlm.nih.gov/pubmed/25662106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn504025a
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