Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer

Cancer cells are known to execute reprogramed metabolism of glucose, amino acids and lipids. Here, we report a significant role of cholesterol metabolism in cancer metastasis. By using label-free Raman spectromicroscopy, we found an aberrant accumulation of cholesteryl ester in human pancreatic canc...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Li, J, Gu, D, Lee, S S-Y, Song, B, Bandyopadhyay, S, Chen, S, Konieczny, S F, Ratliff, T L, Liu, X, Xie, J, Cheng, J-X
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093084/
https://ncbi.nlm.nih.gov/pubmed/27132508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.168
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