Results of a phase Ib trial of combination immunotherapy with a CD8+ T cell eliciting vaccine and trastuzumab in breast cancer patients

BACKGROUND: CD8+ T cell-eliciting vaccines are being investigated in breast cancer patients. Preclinical data showed that trastuzumab increases the susceptibility of tumor cells to lysis by vaccine-generated CD8+ T cells suggesting potential benefit of a combination immunotherapy strategy. The curre...

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Detalhes bibliográficos
Publicado no:Ann Surg Oncol
Main Authors: Clifton, G. Travis, Litton, Jennifer K., Arrington, Karen, Ponniah, Sathibalan, Ibrahim, Nuhad K., Gall, Victor, Alatrash, Gheath, Peoples, George E., Mittendorf, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908243/
https://ncbi.nlm.nih.gov/pubmed/28315060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-017-5844-0
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