Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas

BRCA1/2-mutated ovarian cancers (OCs) are defective in homologous recombination repair (HRR) of double-strand breaks (DSBs) and thereby sensitive to platinum and PARP inhibitors (PARPis). Multiple PARPis have recently received US Food and Drug Administration (FDA) approval for treatment of OCs, and...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Meghani, Khyati, Fuchs, Walker, Detappe, Alexandre, Drané, Pascal, Gogola, Ewa, Rottenberg, Sven, Jonkers, Jos, Matulonis, Ursula, Swisher, Elizabeth M., Konstantinopoulos, Panagiotis A., Chowdhury, Dipanjan
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908239/
https://ncbi.nlm.nih.gov/pubmed/29617652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.038
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