Platinum and PARP inhibitor resistance due to over-expression of microRNA-622 in BRCA1-mutant ovarian cancer

High-grade serous ovarian carcinomas (HGSOCs) with BRCA1/2 mutations exhibit improved outcome and sensitivity to double-strand DNA break (DSB)-inducing agents [i.e. platinum and Poly(ADP-ribose) polymerase inhibitors (PARPis)] due to an underlying defect in homologous recombination (HR). However, re...

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Pubblicato in:Cell Rep
Autori principali: Choi, Young Eun, Meghani, Khyati, Brault, Marie-Eve, Leclerc, Lucas, He, Yizhou J, Day, Tovah A, Elias, Kevin M, Drapkin, Ronny, Weinstock, David M, Dao, Fanny, Shih, Karin K., Matulonis, Ursula, Levine, Douglas A., Konstantinopoulos, Panagiotis A., Chowdhury, Dipanjan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731274/
https://ncbi.nlm.nih.gov/pubmed/26774475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.046
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