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Functional relevance of in vivo half antibody exchange of an IgG4 therapeutic antibody-drug conjugate
An increasing number of monoclonal antibodies and derivatives such as antibody-drug conjugates (ADC) are of the IgG1 and IgG4 isotype with distinct structural and functional properties. In cases where antibody-mediated cytotoxicity is not desired, IgG4 is often used, as its Fc region is relatively p...
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| Foilsithe in: | PLoS One |
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| Main Authors: | , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Public Library of Science
2018
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5908158/ https://ncbi.nlm.nih.gov/pubmed/29672587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195823 |
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