Small ubiquitin-like modifier 1 modification of pyruvate kinase M2 promotes aerobic glycolysis and cell proliferation in A549 human lung cancer cells

OBJECTIVE: Lung cancer is the leading cause of cancer-related death worldwide. Aerobic glycolysis is considered the seventh hallmark of cancer. The M2 isoform of pyruvate kinase (PKM2) is an important rate-limiting enzyme in glycolytic pathway, and is strongly expressed in several types of cancer. T...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Onco Targets Ther
Prif Awduron: An, Shuxian, Huang, Liangqian, Miao, Ping, Shi, Liang, Shen, Mengqin, Zhao, Xiaoping, Liu, Jianjun, Huang, Gang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Dove Medical Press 2018
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5907896/
https://ncbi.nlm.nih.gov/pubmed/29713182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S156918
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