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β-Catenin Deficiency in Hepatocytes Aggravates Hepatocarcinogenesis Driven by Oncogenic β-Catenin and MET

Both activating and inactivating mutations in ctnnb1, encoding β-catenin, have been implicated in liver tumorigenesis in humans and mice, although the underlying mechanisms are not fully understood. Herein we show that deletion of endogenous β-catenin in hepatocytes aggravated hepatocellular carcino...

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Détails bibliographiques
Publié dans:Hepatology
Auteurs principaux: Liang, Yan, Feng, Yun, Zong, Min, Wei, Xufu, Lee, Jin, Feng, Yukuan, Li, Hairi, Yang, Guangshun, Wu, Zhong-Jun, Fu, Xiang-Dong, Feng, Gen-Sheng
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906147/
https://ncbi.nlm.nih.gov/pubmed/29152756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29661
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