Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells

Concomitant activation of the Wnt pathway and suppression of Mapk signaling by two small molecules in the presence of LIF (2i/L) induces a naïve state in mouse embryonic stem cells (ESCs) that resembles the inner cell mass (ICM) of the pre-implantation embryo(1). Since the ICM exists only transientl...

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Publicat a:Nature
Autors principals: Choi, Jiho, Huebner, Aaron J, Clement, Kendell, Walsh, Ryan M, Savol, Andrej, Lin, Kaixuan, Gu, Hongcang, Di Stefano, Bruno, Brumbaugh, Justin, Kim, Sang-Yong, Sharif, Jafar, Rose, Christopher M., Mohammad, Arman, Odajima, Junko, Charron, Jean, Shioda, Toshi, Gnirke, Andreas, Gygi, Steven, Koseki, Haruhiko, Sadreyev, Ruslan I., Xiao, Andrew, Meissner, Alexander, Hochedlinger, Konrad
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5905676/
https://ncbi.nlm.nih.gov/pubmed/28746311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23274
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