Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene

BACKGROUND: Improvement in genetic characterization of Colon Cancer (CC) patients is required to propose new potential targets, since surgical resection coupled to chemotherapy, presents several limits such as cancer recurrence and drug resistance. Targeted therapies have more efficacy and less toxi...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Mendes Oliveira, Duarte, Grillone, Katia, Mignogna, Chiara, De Falco, Valentina, Laudanna, Carmelo, Biamonte, Flavia, Locane, Rosa, Corcione, Francesco, Fabozzi, Massimiliano, Sacco, Rosario, Viglietto, Giuseppe, Malanga, Donatella, Rizzuto, Antonia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5905113/
https://ncbi.nlm.nih.gov/pubmed/29665843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0746-y
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