Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene

BACKGROUND: Improvement in genetic characterization of Colon Cancer (CC) patients is required to propose new potential targets, since surgical resection coupled to chemotherapy, presents several limits such as cancer recurrence and drug resistance. Targeted therapies have more efficacy and less toxi...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Mendes Oliveira, Duarte, Grillone, Katia, Mignogna, Chiara, De Falco, Valentina, Laudanna, Carmelo, Biamonte, Flavia, Locane, Rosa, Corcione, Francesco, Fabozzi, Massimiliano, Sacco, Rosario, Viglietto, Giuseppe, Malanga, Donatella, Rizzuto, Antonia
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5905113/
https://ncbi.nlm.nih.gov/pubmed/29665843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0746-y
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