Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene

BACKGROUND: Improvement in genetic characterization of Colon Cancer (CC) patients is required to propose new potential targets, since surgical resection coupled to chemotherapy, presents several limits such as cancer recurrence and drug resistance. Targeted therapies have more efficacy and less toxi...

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Bibliografische gegevens
Gepubliceerd in:J Exp Clin Cancer Res
Hoofdauteurs: Mendes Oliveira, Duarte, Grillone, Katia, Mignogna, Chiara, De Falco, Valentina, Laudanna, Carmelo, Biamonte, Flavia, Locane, Rosa, Corcione, Francesco, Fabozzi, Massimiliano, Sacco, Rosario, Viglietto, Giuseppe, Malanga, Donatella, Rizzuto, Antonia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2018
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5905113/
https://ncbi.nlm.nih.gov/pubmed/29665843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0746-y
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