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BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology
BACE1 is the rate-limiting protease in the production of synaptotoxic β-amyloid (Aβ) species and hence one of the prime drug targets for potential therapy of Alzheimer’s disease (AD). However, so far pharmacological BACE1 inhibition failed to rescue the cognitive decline in mild-to-moderate AD patie...
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| 出版年: | Acta Neuropathol |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer Berlin Heidelberg
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5904228/ https://ncbi.nlm.nih.gov/pubmed/29327084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1804-9 |
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