BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology

BACE1 is the rate-limiting protease in the production of synaptotoxic β-amyloid (Aβ) species and hence one of the prime drug targets for potential therapy of Alzheimer’s disease (AD). However, so far pharmacological BACE1 inhibition failed to rescue the cognitive decline in mild-to-moderate AD patie...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Peters, Finn, Salihoglu, Hazal, Rodrigues, Eva, Herzog, Etienne, Blume, Tanja, Filser, Severin, Dorostkar, Mario, Shimshek, Derya R., Brose, Nils, Neumann, Ulf, Herms, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2018
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5904228/
https://ncbi.nlm.nih.gov/pubmed/29327084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1804-9
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