Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier

BACKGROUND & AIMS: Neural Wiskott-Aldrich Syndrome protein (N-WASP) is a key regulator of the actin cytoskeleton in epithelial tissues and is poised to mediate cytoskeletal-dependent aspects of apical junction complex (AJC) homeostasis. Attaching-and-effacing (AE) pathogens disrupt this homeosta...

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Udgivet i:Cell Mol Gastroenterol Hepatol
Main Authors: Garber, John J., Mallick, Emily M., Scanlon, Karen M., Turner, Jerrold R., Donnenberg, Michael S., Leong, John M., Snapper, Scott B.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5904039/
https://ncbi.nlm.nih.gov/pubmed/29675452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2017.11.015
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