Effect of the angiotensin receptor–neprilysin inhibitor sacubitril/valsartan on the pharmacokinetics and pharmacodynamics of a single dose of furosemide

AIMS: Sacubitril/valsartan is indicated for the treatment of heart failure and reduced ejection fraction (HFrEF). Furosemide, a loop diuretic commonly used for the treatment of HFrEF, may be coadministered with sacubitril/valsartan in clinical practice. The effect of sacubitril/valsartan on the phar...

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Bibliographic Details
Published in:Br J Clin Pharmacol
Main Authors: Ayalasomayajula, Surya, Schuehly, Uwe, Pal, Parasar, Chen, Fabian, Zhou, Wei, Sunkara, Gangadhar, Langenickel, Thomas H.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
Subjects:
Pharmacokinetic Dynamic Relationships
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903241/
https://ncbi.nlm.nih.gov/pubmed/29318651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13505
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