Pharmacodynamic and Pharmacokinetic Profiles of Sacubitril/Valsartan (LCZ696) in Patients with Heart Failure and Reduced Ejection Fraction

AIMS: Concomitant renin–angiotensin–aldosterone system blockade and natriuretic peptide system enhancement may provide unique therapeutic benefits to patients with heart failure and reduced ejection fraction (HFrEF). This study assessed the pharmacodynamics and pharmacokinetics of LCZ696 in patients...

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Bibliographische Detailangaben
Veröffentlicht in:Cardiovasc Ther
Hauptverfasser: Kobalava, Zhanna, Kotovskaya, Yulia, Averkov, Oleg, Pavlikova, Elena, Moiseev, Valentine, Albrecht, Diego, Chandra, Priya, Ayalasomayajula, Surya, Prescott, Margaret F., Pal, Parasar, Langenickel, Thomas H., Jordaan, Pierre, Rajman, Iris
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Original Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108443/
https://ncbi.nlm.nih.gov/pubmed/26990595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1755-5922.12183
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