Tolerogenic Ag-PLG Nanoparticles Induce Tregs to Suppress Activated Diabetogenic CD4 and CD8 T Cells

Type 1 diabetes (T1D) is mediated by destruction of pancreatic β cells by autoantigen-specific CD4(+) and CD8(+) T cells, thus the ideal solution for T1D is the restoration of immune tolerance to β cell antigens. We demonstrate the ability of carboxylated 500nm biodegradable poly(lactide-co-glycolid...

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Bibliographic Details
Published in:J Autoimmun
Main Authors: Prasad, Suchitra, Neef, Tobias, Xu, Dan, Podojil, Joseph R., Getts, Daniel R., Shea, Lonnie D., Miller, Stephen D.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5902637/
https://ncbi.nlm.nih.gov/pubmed/29258717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2017.12.010
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