Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization

Specific immunotherapy (SIT) is the most widely used treatment for allergic diseases that directly targets the T helper 2 (Th2) bias underlying allergy. However, the most widespread clinical applications of SIT require a long period of dose escalation with soluble antigen (Ag) and carry a significan...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Smarr, Charles B., Yap, Woon Teck, Neef, Tobias P., Pearson, Ryan M., Hunter, Zoe N., Ifergan, Igal, Getts, Daniel R., Bryce, Paul J., Shea, Lonnie D., Miller, Stephen D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983813/
https://ncbi.nlm.nih.gov/pubmed/27091976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505782113
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