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Piwi is required to limit exhaustion of aging somatic stem cells

Sophisticated mechanisms that preserve genome integrity are critical to ensure the maintenance of regenerative capacity while preventing transformation of somatic stem cells (SCs), yet little is known about mechanisms regulating genome maintenance in these cells. Here we show that intestinal stem ce...

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Detalles Bibliográficos
Publicado en:Cell Rep
Autores principales: Sousa-Victor, Pedro, Ayyaz, Arshad, Hayashi, Rippei, Qi, Yanyan, Madden, David T, Lunyak, Victoria V, Jasper, Heinrich
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5901960/
https://ncbi.nlm.nih.gov/pubmed/28903034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.059
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