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PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress

Intestinal homeostasis requires precise control of intestinal stem cell (ISC) proliferation. In Drosophila, this control declines with age largely due to chronic activation of stress signaling and associated chronic inflammatory conditions. An important contributor to this condition is the age-assoc...

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Vydáno v:PLoS Genet
Hlavní autoři: Wang, Lifen, Ryoo, Hyung Don, Qi, Yanyan, Jasper, Heinrich
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422665/
https://ncbi.nlm.nih.gov/pubmed/25945494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005220
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