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Piwi is required to limit exhaustion of aging somatic stem cells

Sophisticated mechanisms that preserve genome integrity are critical to ensure the maintenance of regenerative capacity while preventing transformation of somatic stem cells (SCs), yet little is known about mechanisms regulating genome maintenance in these cells. Here we show that intestinal stem ce...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Sousa-Victor, Pedro, Ayyaz, Arshad, Hayashi, Rippei, Qi, Yanyan, Madden, David T, Lunyak, Victoria V, Jasper, Heinrich
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5901960/
https://ncbi.nlm.nih.gov/pubmed/28903034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.059
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