Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the “NNRTI Adjacent” Binding Site

[Image: see text] A novel series of diarylpyrimidine derivatives, which could simultaneously occupy the classical NNRTIs binding pocket (NNIBP) and the newly reported “NNRTI Adjacent” binding site, were designed, synthesized, and evaluated for their antiviral activities in MT-4 cell cultures. The re...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Huo, Zhipeng, Zhang, Heng, Kang, Dongwei, Zhou, Zhongxia, Wu, Gaochan, Desta, Samuel, Zuo, Xiaofang, Wang, Zhao, Jing, Lanlan, Ding, Xiao, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900322/
https://ncbi.nlm.nih.gov/pubmed/29670696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00524
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