Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the “NNRTI Adjacent” Binding Site

[Image: see text] A novel series of diarylpyrimidine derivatives, which could simultaneously occupy the classical NNRTIs binding pocket (NNIBP) and the newly reported “NNRTI Adjacent” binding site, were designed, synthesized, and evaluated for their antiviral activities in MT-4 cell cultures. The re...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Huo, Zhipeng, Zhang, Heng, Kang, Dongwei, Zhou, Zhongxia, Wu, Gaochan, Desta, Samuel, Zuo, Xiaofang, Wang, Zhao, Jing, Lanlan, Ding, Xiao, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2018
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900322/
https://ncbi.nlm.nih.gov/pubmed/29670696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00524
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