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High-Affinity Ligands Can Trigger T Cell Receptor Signaling Without CD45 Segregation
How T cell receptors (TCRs) are triggered to start signaling is still not fully understood. It has been proposed that segregation of the large membrane tyrosine phosphatase CD45 from engaged TCRs initiates signaling by favoring phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAM...
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| Опубликовано в: : | Front Immunol |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Frontiers Media S.A.
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5900011/ https://ncbi.nlm.nih.gov/pubmed/29686683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00713 |
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