Experimental and Computational Insight into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity

RATIONALE: Myocardial delivery of human mesenchymal stem cells (hMSCs) is an emerging therapy for treating the failing heart. However, the relative effects of hMSC-mediated heterocellular coupling (HC) and paracrine signaling (PS) on human cardiac contractility and arrhythmogenicity remain unresolve...

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Publicado en:Circ Res
Autores principales: Mayourian, Joshua, Cashman, Timothy J., Ceholski, Delaine K., Johnson, Bryce V., Sachs, David, Kaji, Deepak A., Sahoo, Susmita, Hare, Joshua M., Hajjar, Roger J., Sobie, Eric A., Costa, Kevin D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899516/
https://ncbi.nlm.nih.gov/pubmed/28642329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.310796
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