Adeno-associated virus Rep proteins antagonize phosphatase PP1 to counteract KAP1 repression of the latent viral genome

Adeno-associated virus (AAV) is a small human Dependovirus whose low immunogenicity and capacity for long-term persistence have led to its widespread use as vector for gene therapy. Despite great recent successes in AAV-based gene therapy, further improvements in vector technology may be hindered by...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Smith-Moore, Sarah, Neil, Stuart J. D., Fraefel, Cornel, Linden, R. Michael, Bollen, Mathieu, Rowe, Helen M., Henckaerts, Els
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899473/
https://ncbi.nlm.nih.gov/pubmed/29581310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721883115
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