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Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failure
Heart disease is associated with the accumulation of resident cardiac fibroblasts (CFs) that secrete extracellular matrix (ECM), leading to the development of pathological fibrosis and heart failure. However, the mechanisms underlying resident CF proliferation remain poorly defined. Here, we report...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5899445/ https://ncbi.nlm.nih.gov/pubmed/29581288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717423115 |
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