Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failure

Heart disease is associated with the accumulation of resident cardiac fibroblasts (CFs) that secrete extracellular matrix (ECM), leading to the development of pathological fibrosis and heart failure. However, the mechanisms underlying resident CF proliferation remain poorly defined. Here, we report...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Burke, Ryan M., Lighthouse, Janet K., Quijada, Pearl, Dirkx, Ronald A., Rosenberg, Alexander, Moravec, Christine S., Alexis, Jeffrey D., Small, Eric M.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899445/
https://ncbi.nlm.nih.gov/pubmed/29581288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717423115
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