Correlation of plasma concentration and adverse effects of bosutinib: standard dose or dose-escalation regimens of bosutinib treatment for patients with chronic myeloid leukemia

PURPOSE: To investigate the exposure-toxicity relationship of bosutinib and to identify the target trough plasma concentration (C(0)). METHODS: The toxicity and C(0) of bosutinib in Japanese chronic myeloid leukemia (CML) patients were monitored every 2 weeks for the first 3 months of treatment, and...

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Dettagli Bibliografici
Pubblicato in:Exp Hematol Oncol
Autori principali: Mita, Akiko, Abumiya, Maiko, Miura, Masatomo, Niioka, Takenori, Takahashi, Saori, Yoshioka, Tomoko, Kameoka, Yoshihiro, Takahashi, Naoto
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899348/
https://ncbi.nlm.nih.gov/pubmed/29682402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40164-018-0101-1
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