Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis

Muscle atrophy with weakness is a core feature of amyotrophic lateral sclerosis (ALS) that has long been attributed to motor neuron loss alone. However, several studies in ALS patients, and more so in animal models, have challenged this assumption with the latter providing direct evidence that muscl...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Cykowski, Matthew D., Powell, Suzanne Z., Appel, Joan W., Arumanayagam, Anithachristy S., Rivera, Andreana L., Appel, Stanley H.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899326/
https://ncbi.nlm.nih.gov/pubmed/29653597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0528-y
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