Loading...
Endosomal Escape of Antisense Oligonucleotides Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 During Endosomal Maturation
Second-generation (Gen 2) Antisense oligonucleotides (ASOs) show increased nuclease stability and affinity for their RNA targets, which has translated to improved potency and therapeutic index in the clinic. Gen 2 ASOs are typically modified using the phosphorothioate (PS) backbone modification, whi...
Na minha lista:
| Udgivet i: | Nucleic Acid Ther |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Mary Ann Liebert, Inc.
2018
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5899299/ https://ncbi.nlm.nih.gov/pubmed/29437530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2017.0694 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|