Dynamics of Evolution of Poliovirus Neutralizing Antigenic Sites and Other Capsid Functional Domains during a Large and Prolonged Outbreak

We followed the dynamics of capsid amino acid replacement among 403 Nigerian outbreak isolates of type 2 circulating vaccine-derived poliovirus (cVDPV2) from 2005 through 2011. Four different functional domains were analyzed: (i) neutralizing antigenic (NAg) sites, (ii) residues binding the poliovir...

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Publicado en:J Virol
Autores principales: Shaw, Jing, Jorba, Jaume, Zhao, Kun, Iber, Jane, Chen, Qi, Adu, Festus, Adeniji, Adekunle, Bukbuk, David, Baba, Marycelin, Henderson, Elizabeth, Dybdahl-Sissoko, Naomi, McDonald, Sharla, Weldon, William C., Gumede, Nicksy, Oberste, M. Steven, Kew, Olen M., Burns, Cara C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2018
Materias:
Genetic Diversity and Evolution
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899205/
https://ncbi.nlm.nih.gov/pubmed/29444940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01949-17
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