Modulation of Poliovirus Replicative Fitness in HeLa Cells by Deoptimization of Synonymous Codon Usage in the Capsid Region

We replaced degenerate codons for nine amino acids within the capsid region of the Sabin type 2 oral poliovirus vaccine strain with corresponding nonpreferred synonymous codons. Codon replacements were introduced into four contiguous intervals spanning 97% of the capsid region. In the capsid region...

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Detalhes bibliográficos
Main Authors: Burns, Cara Carthel, Shaw, Jing, Campagnoli, Ray, Jorba, Jaume, Vincent, Annelet, Quay, Jacqueline, Kew, Olen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440415/
https://ncbi.nlm.nih.gov/pubmed/16537593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.7.3259-3272.2006
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