Modulation of Poliovirus Replicative Fitness in HeLa Cells by Deoptimization of Synonymous Codon Usage in the Capsid Region

We replaced degenerate codons for nine amino acids within the capsid region of the Sabin type 2 oral poliovirus vaccine strain with corresponding nonpreferred synonymous codons. Codon replacements were introduced into four contiguous intervals spanning 97% of the capsid region. In the capsid region...

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Bibliografski detalji
Glavni autori: Burns, Cara Carthel, Shaw, Jing, Campagnoli, Ray, Jorba, Jaume, Vincent, Annelet, Quay, Jacqueline, Kew, Olen
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
Teme:
Genetic Diversity and Evolution
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440415/
https://ncbi.nlm.nih.gov/pubmed/16537593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.7.3259-3272.2006
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